Our R21 grant on secondary data analysis of public data for age-related macular degeneration is funded. In this project, we will perform novel statistical analysis on publicly available gene expression and genetics data to characterize cell type composition and cell type-specific gene expression changes in human retina, and to elucidate the functional roles of genetic findings on age-related macular degeneration.
Our R01 grant on single-cell study in age-macular degeneration is funded. In collaboration with Dwight Stambolian in the Department of Ophthalmology, we will collect and analyze cells from postmortem human eyes to address the question about what cell types are involved in age-related macular degeneration.
Our administrative supplement on Alzheimer’s disease will also be funded. In this project, we will generate data from retina in Alzheimer’s disease patients to test the hypothesis that measurable molecular deficits occur in the retinas of individuals diagnosed with Alzheimer’s disease.