Lab News

Our R01 grant on "Computational and functional strategies to decipher lncRNAs in human atherosclerosis" will be funded

In this joint project with Dr. Muredach Reilly, we propose innovative integration of large-scale bulk RNA-seq coupled to single-cell RNA-seq profiling of human atherosclerotic plaques and novel deconvolution algorithms to identify lncRNAs, and their host cell subpopulations, for atherosclerosis. These findings, coupled to our cell-specific functional genomic studies, will drive in vivo modeling and precision therapeutic targeting of vascular lncRNAs in atherosclerotic cardiovascular disease.


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